Sodium purine nucleoside transporter
نویسندگان
چکیده
منابع مشابه
A purine-selective nucleobase/nucleoside transporter in PK15NTD cells.
Nucleoside and nucleobase transporters are important for salvage of purines and pyrimidines and for transport of their analog drugs into cells. However, the pathways for nucleobase translocation in mammalian cells are not well characterized. We identified an Na-independent purine-selective nucleobase/nucleoside transport system in the nucleoside transporter-deficient PK15NTD cells. This transpo...
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Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is a trimeric enzyme that readily dissociates to the monomer. Dilution of enzyme from 20 to 0.02 pg of protein/ml is accompanied by a greater than 50-fold increase in the specific activity (utrimer = 0.23 nmol/min/pg; umonomer = 12.5 nmol/min/pg). Gel permeation chromatography in the presence of the substrate phosphate shows the en...
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1. Concave-downward double-reciprocal plots were obtained for rabbit erythrocyte purine nucleoside phosphorylase when the concentration of Pi was varied over a wide range at a fixed saturating concentration of either inosine or deoxyinosine. Similar behaviour was also displayed by the calf spleen enzyme. 2. The degree of curvature of double-reciprocal plots was greatly modified by the presence ...
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ducing carcinostasis, with tumor cells resistant to thio guanine, has been suggested (9). The aand @9-anomers of 2'-deoxythioguanosine (TGDR) have been shown to be active against ascites tumors having either of two types of resistance to thioguanine (10). The kinases necessary for conversion of these nucleosides to nucleotides were apparently present in the tumor cell lines examined. How ever, ...
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Wang, Juan, Sheng-Fang Su, Mark J. Dresser, Marci E. Schaner, Carla B. Washington, and Kathleen M. Giacomini. Na1-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am. J. Physiol. 273 (Renal Physiol. 42): F1058–F1065, 1997.— Many purine nucleosides and their analogs are actively transported in the kidney. Using homology cloning strategies and re...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1999
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510290431